Exploration
Accueil
Racine
Exploration
Accueil
Racine

Serveur d'exploration sur les relations entre la France et l'Australie

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Genome-Wide Association Study Identifies Variants Associated with Progression of Liver Fibrosis from HCV Infection

Identifieur interne : 005376 ( Main/Exploration ); précédent : 005375; suivant : 005377

Genome-Wide Association Study Identifies Variants Associated with Progression of Liver Fibrosis from HCV Infection

Auteurs : Etienne Patin [France] ; Zoltán Kutalik [Suisse] ; Julien Guergnon [France] ; Stéphanie Bibert [Suisse] ; Bertrand Nalpas [France] ; Emmanuelle Jouanguy [France, États-Unis] ; Mona Munteanu [France] ; Laurence Bousquet [France] ; Laurent Argiro [France] ; Philippe Halfon [France] ; Anne Boland [France] ; Beat Müllhaupt [Suisse] ; David Semela [Suisse] ; Jean-François Dufour [Suisse] ; Markus H. Heim [Suisse] ; Darius Moradpour [Suisse] ; Andreas Cerny [Suisse] ; Raffaele Malinverni [Suisse] ; Hans Hirsch [Suisse] ; Gladys Martinetti [Suisse] ; Vijayaprakash Suppiah [Australie] ; Graeme Stewart [Australie] ; David R. Booth [Australie] ; Jacob George [Australie] ; Jean-Laurent Casanova [France, États-Unis] ; Christian Bréchot [France] ; Charles M. Rice [États-Unis] ; Andrew H. Talal [États-Unis] ; Ira M. Jacobson [États-Unis] ; Marc Bourlière [France] ; Ioannis Theodorou [France] ; Thierry Poynard [France] ; Francesco Negro [Suisse] ; Stanislas Pol [France] ; Pierre-Yves Bochud [Suisse] ; Laurent Abel [France, États-Unis]

Source :

RBID : PMC:3756935

Abstract

BACKGROUND & AIMS

Polymorphisms in IL28B were shown to affect clearance of hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We carried out a 2-stage GWA study of liver fibrosis progression related to HCV infection.

METHODS

We studied well-characterized HCV-infected patients of European descent who had liver biopsies before treatment. We defined various liver fibrosis phenotypes on the basis of Metavir scores, with and without taking the duration of HCV infection into account. Our GWA analyses were conducted on a filtered primary cohort of 1161 patients using 780,650 single nucleotide polymorphisms (SNPs). We genotyped 96 SNPs with P-values<5×10−5 from an independent replication cohort of 962 patients. We then assessed the most interesting replicated SNPs using DNA samples collected from 219 patients who participated in separate GWA studies of HCV clearance.

RESULTS

In the combined cohort of 2342 HCV-infected patients, the SNPs rs16851720 (in the total sample) and rs4374383 (in patients that received blood transfusions) were associated with fibrosis progression (Pcombined=8.9×10−9 and 1.1×10−9, respectively). The SNP rs16851720 is located within RNF7, which encodes an antioxidant that protects against apoptosis. The SNP rs4374383, together with another replicated SNP, rs9380516 (Pcombined=5.4×10−7), were linked to the functionally related genes MERTK and TULP1, which encode factors involved in phagocytosis of apoptotic cells by macrophages.

CONCLUSIONS

Our GWA study identified several susceptibility loci for HCV-induced liver fibrosis; these were linked to genes that regulate apoptosis. Apoptotic control might therefore be involved in liver fibrosis.


Url:
DOI: 10.1053/j.gastro.2012.07.097
PubMed: 22841784
PubMed Central: 3756935


Affiliations:

Links toward previous steps (curation, corpus...)

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Genome-Wide Association Study Identifies Variants Associated with Progression of Liver Fibrosis from HCV Infection</title>
<author>
<name sortKey="Patin, Etienne" sort="Patin, Etienne" uniqKey="Patin E" first="Etienne" last="Patin">Etienne Patin</name>
<affiliation wicri:level="3">
<nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name>
<affiliation wicri:level="3">
<nlm:aff id="A3">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Medical Genetics, University of Lausanne, Lausanne</wicri:regionArea>
<placeName>
<settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A4">Swiss Institute of Bioinformatics, Lausanne, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea>
<placeName>
<settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Guergnon, Julien" sort="Guergnon, Julien" uniqKey="Guergnon J" first="Julien" last="Guergnon">Julien Guergnon</name>
<affiliation wicri:level="3">
<nlm:aff id="A5">Laboratory of Immunity and Infection, INSERM UMR-S 945, UPMC Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière AP-HP, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Immunity and Infection, INSERM UMR-S 945, UPMC Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière AP-HP, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bibert, Stephanie" sort="Bibert, Stephanie" uniqKey="Bibert S" first="Stéphanie" last="Bibert">Stéphanie Bibert</name>
<affiliation wicri:level="3">
<nlm:aff id="A6">Service of Infectious Diseases, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Service of Infectious Diseases, Department of Medicine, University Hospital and University of Lausanne, Lausanne</wicri:regionArea>
<placeName>
<settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nalpas, Bertrand" sort="Nalpas, Bertrand" uniqKey="Nalpas B" first="Bertrand" last="Nalpas">Bertrand Nalpas</name>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A7">Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name>
<affiliation wicri:level="3">
<nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A8">St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Munteanu, Mona" sort="Munteanu, Mona" uniqKey="Munteanu M" first="Mona" last="Munteanu">Mona Munteanu</name>
<affiliation wicri:level="3">
<nlm:aff id="A9">Biopredictive, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Biopredictive, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bousquet, Laurence" sort="Bousquet, Laurence" uniqKey="Bousquet L" first="Laurence" last="Bousquet">Laurence Bousquet</name>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A7">Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Argiro, Laurent" sort="Argiro, Laurent" uniqKey="Argiro L" first="Laurent" last="Argiro">Laurent Argiro</name>
<affiliation wicri:level="4">
<nlm:aff id="A10">Laboratoire d’Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d’Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles</wicri:regionArea>
<wicri:noRegion>Marseilles</wicri:noRegion>
<orgName type="university">Université de la Méditerranée</orgName>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Halfon, Philippe" sort="Halfon, Philippe" uniqKey="Halfon P" first="Philippe" last="Halfon">Philippe Halfon</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles</wicri:regionArea>
<wicri:noRegion>Marseilles</wicri:noRegion>
<wicri:noRegion>Marseilles</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name>
<affiliation wicri:level="3">
<nlm:aff id="A12">CEA, Institut de Génomique, Centre National de Génotypage, Evry, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CEA, Institut de Génomique, Centre National de Génotypage, Evry</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mullhaupt, Beat" sort="Mullhaupt, Beat" uniqKey="Mullhaupt B" first="Beat" last="Müllhaupt">Beat Müllhaupt</name>
<affiliation wicri:level="1">
<nlm:aff id="A13">Division of Gastroenterology and Hepatology, University Hospital, Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, University Hospital, Zurich</wicri:regionArea>
<wicri:noRegion>Zurich</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Semela, David" sort="Semela, David" uniqKey="Semela D" first="David" last="Semela">David Semela</name>
<affiliation wicri:level="1">
<nlm:aff id="A14">Division of Gastroenterology, Canton Hospital, St Gallen, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Gastroenterology, Canton Hospital, St Gallen</wicri:regionArea>
<wicri:noRegion>St Gallen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Dufour, Jean Francois" sort="Dufour, Jean Francois" uniqKey="Dufour J" first="Jean-François" last="Dufour">Jean-François Dufour</name>
<affiliation wicri:level="3">
<nlm:aff id="A15">Hepatology, Department of Clinical Research, University Clinic for visceral Surgery and Medicine, Bern, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Hepatology, Department of Clinical Research, University Clinic for visceral Surgery and Medicine, Bern</wicri:regionArea>
<placeName>
<settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Heim, Markus H" sort="Heim, Markus H" uniqKey="Heim M" first="Markus H." last="Heim">Markus H. Heim</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Division of Gastroenterology and Hepatology, University Hospital, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, University Hospital, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Moradpour, Darius" sort="Moradpour, Darius" uniqKey="Moradpour D" first="Darius" last="Moradpour">Darius Moradpour</name>
<affiliation wicri:level="1">
<nlm:aff id="A17">Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Centre Hospitalier Universitaire Vaudois, University of Lausanne</wicri:regionArea>
<wicri:noRegion>University of Lausanne</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Cerny, Andreas" sort="Cerny, Andreas" uniqKey="Cerny A" first="Andreas" last="Cerny">Andreas Cerny</name>
<affiliation wicri:level="1">
<nlm:aff id="A18">Clinica Moncucco, Lugano, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Clinica Moncucco, Lugano</wicri:regionArea>
<wicri:noRegion>Lugano</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Malinverni, Raffaele" sort="Malinverni, Raffaele" uniqKey="Malinverni R" first="Raffaele" last="Malinverni">Raffaele Malinverni</name>
<affiliation wicri:level="1">
<nlm:aff id="A19">Pourtalès Hospital, Neuchâtel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Pourtalès Hospital, Neuchâtel</wicri:regionArea>
<wicri:noRegion>Neuchâtel</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hirsch, Hans" sort="Hirsch, Hans" uniqKey="Hirsch H" first="Hans" last="Hirsch">Hans Hirsch</name>
<affiliation wicri:level="1">
<nlm:aff id="A20">Institute for Medical Microbiology, University Hospital, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute for Medical Microbiology, University Hospital, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Martinetti, Gladys" sort="Martinetti, Gladys" uniqKey="Martinetti G" first="Gladys" last="Martinetti">Gladys Martinetti</name>
<affiliation wicri:level="1">
<nlm:aff id="A21">Institute of Medical Microbiology, Bellinzona, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Medical Microbiology, Bellinzona</wicri:regionArea>
<wicri:noRegion>Bellinzona</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Suppiah, Vijayaprakash" sort="Suppiah, Vijayaprakash" uniqKey="Suppiah V" first="Vijayaprakash" last="Suppiah">Vijayaprakash Suppiah</name>
<affiliation wicri:level="3">
<nlm:aff id="A22">Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A23">Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author>
<name sortKey="Stewart, Graeme" sort="Stewart, Graeme" uniqKey="Stewart G" first="Graeme" last="Stewart">Graeme Stewart</name>
<affiliation wicri:level="4">
<nlm:aff id="A23">Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author>
<name sortKey="Booth, David R" sort="Booth, David R" uniqKey="Booth D" first="David R." last="Booth">David R. Booth</name>
<affiliation wicri:level="4">
<nlm:aff id="A23">Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author>
<name sortKey="George, Jacob" sort="George, Jacob" uniqKey="George J" first="Jacob" last="George">Jacob George</name>
<affiliation wicri:level="3">
<nlm:aff id="A22">Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name>
<affiliation wicri:level="3">
<nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A8">St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Brechot, Christian" sort="Brechot, Christian" uniqKey="Brechot C" first="Christian" last="Bréchot">Christian Bréchot</name>
<affiliation wicri:level="1">
<nlm:aff id="A24">INSERM U785, Liver Hepatology Centre, Paul Brousse Hospital, University Paris-XI, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U785, Liver Hepatology Centre, Paul Brousse Hospital, University Paris-XI, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Rice, Charles M" sort="Rice, Charles M" uniqKey="Rice C" first="Charles M." last="Rice">Charles M. Rice</name>
<affiliation wicri:level="2">
<nlm:aff id="A25">Center for the Study of Hepatitis C, Rockefeller University, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for the Study of Hepatitis C, Rockefeller University, New York</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Talal, Andrew H" sort="Talal, Andrew H" uniqKey="Talal A" first="Andrew H." last="Talal">Andrew H. Talal</name>
<affiliation wicri:level="2">
<nlm:aff id="A26">Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M." last="Jacobson">Ira M. Jacobson</name>
<affiliation wicri:level="2">
<nlm:aff id="A26">Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bourliere, Marc" sort="Bourliere, Marc" uniqKey="Bourliere M" first="Marc" last="Bourlière">Marc Bourlière</name>
<affiliation wicri:level="1">
<nlm:aff id="A27">Service d’Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d’Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles</wicri:regionArea>
<wicri:noRegion>Marseilles</wicri:noRegion>
<wicri:noRegion>Marseilles</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Theodorou, Ioannis" sort="Theodorou, Ioannis" uniqKey="Theodorou I" first="Ioannis" last="Theodorou">Ioannis Theodorou</name>
<affiliation wicri:level="3">
<nlm:aff id="A5">Laboratory of Immunity and Infection, INSERM UMR-S 945, UPMC Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière AP-HP, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Immunity and Infection, INSERM UMR-S 945, UPMC Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière AP-HP, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Poynard, Thierry" sort="Poynard, Thierry" uniqKey="Poynard T" first="Thierry" last="Poynard">Thierry Poynard</name>
<affiliation wicri:level="4">
<nlm:aff id="A28">Université Pierre et Marie Curie, Service d’Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Pierre et Marie Curie, Service d’Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Pierre-et-Marie-Curie</orgName>
</affiliation>
</author>
<author>
<name sortKey="Negro, Francesco" sort="Negro, Francesco" uniqKey="Negro F" first="Francesco" last="Negro">Francesco Negro</name>
<affiliation wicri:level="1">
<nlm:aff id="A29">Divisions of Gastroenterology and Hepatology and of Clinical Pathology, University Hospital, Geneva, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Divisions of Gastroenterology and Hepatology and of Clinical Pathology, University Hospital, Geneva</wicri:regionArea>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A7">Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bochud, Pierre Yves" sort="Bochud, Pierre Yves" uniqKey="Bochud P" first="Pierre-Yves" last="Bochud">Pierre-Yves Bochud</name>
<affiliation wicri:level="3">
<nlm:aff id="A6">Service of Infectious Diseases, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Service of Infectious Diseases, Department of Medicine, University Hospital and University of Lausanne, Lausanne</wicri:regionArea>
<placeName>
<settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name>
<affiliation wicri:level="3">
<nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A8">St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">22841784</idno>
<idno type="pmc">3756935</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756935</idno>
<idno type="RBID">PMC:3756935</idno>
<idno type="doi">10.1053/j.gastro.2012.07.097</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">001D09</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D09</idno>
<idno type="wicri:Area/Pmc/Curation">001B66</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001B66</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001F31</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001F31</idno>
<idno type="wicri:Area/Ncbi/Merge">000F13</idno>
<idno type="wicri:Area/Ncbi/Curation">000F13</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000F13</idno>
<idno type="wicri:doubleKey">0016-5085:2012:Patin E:genome:wide:association</idno>
<idno type="wicri:Area/Main/Merge">005615</idno>
<idno type="wicri:Area/Main/Curation">005376</idno>
<idno type="wicri:Area/Main/Exploration">005376</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Genome-Wide Association Study Identifies Variants Associated with Progression of Liver Fibrosis from HCV Infection</title>
<author>
<name sortKey="Patin, Etienne" sort="Patin, Etienne" uniqKey="Patin E" first="Etienne" last="Patin">Etienne Patin</name>
<affiliation wicri:level="3">
<nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name>
<affiliation wicri:level="3">
<nlm:aff id="A3">Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Medical Genetics, University of Lausanne, Lausanne</wicri:regionArea>
<placeName>
<settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A4">Swiss Institute of Bioinformatics, Lausanne, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea>
<placeName>
<settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Guergnon, Julien" sort="Guergnon, Julien" uniqKey="Guergnon J" first="Julien" last="Guergnon">Julien Guergnon</name>
<affiliation wicri:level="3">
<nlm:aff id="A5">Laboratory of Immunity and Infection, INSERM UMR-S 945, UPMC Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière AP-HP, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Immunity and Infection, INSERM UMR-S 945, UPMC Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière AP-HP, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bibert, Stephanie" sort="Bibert, Stephanie" uniqKey="Bibert S" first="Stéphanie" last="Bibert">Stéphanie Bibert</name>
<affiliation wicri:level="3">
<nlm:aff id="A6">Service of Infectious Diseases, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Service of Infectious Diseases, Department of Medicine, University Hospital and University of Lausanne, Lausanne</wicri:regionArea>
<placeName>
<settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nalpas, Bertrand" sort="Nalpas, Bertrand" uniqKey="Nalpas B" first="Bertrand" last="Nalpas">Bertrand Nalpas</name>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A7">Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name>
<affiliation wicri:level="3">
<nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A8">St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Munteanu, Mona" sort="Munteanu, Mona" uniqKey="Munteanu M" first="Mona" last="Munteanu">Mona Munteanu</name>
<affiliation wicri:level="3">
<nlm:aff id="A9">Biopredictive, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Biopredictive, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bousquet, Laurence" sort="Bousquet, Laurence" uniqKey="Bousquet L" first="Laurence" last="Bousquet">Laurence Bousquet</name>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A7">Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Argiro, Laurent" sort="Argiro, Laurent" uniqKey="Argiro L" first="Laurent" last="Argiro">Laurent Argiro</name>
<affiliation wicri:level="4">
<nlm:aff id="A10">Laboratoire d’Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d’Immunologie et de Génétique des Maladies Parasitaires, INSERM-UMR 906/Université de la Méditerranée, Marseilles</wicri:regionArea>
<wicri:noRegion>Marseilles</wicri:noRegion>
<orgName type="university">Université de la Méditerranée</orgName>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Halfon, Philippe" sort="Halfon, Philippe" uniqKey="Halfon P" first="Philippe" last="Halfon">Philippe Halfon</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Alphabio, Hôpital Ambroise Paré, Marseilles</wicri:regionArea>
<wicri:noRegion>Marseilles</wicri:noRegion>
<wicri:noRegion>Marseilles</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name>
<affiliation wicri:level="3">
<nlm:aff id="A12">CEA, Institut de Génomique, Centre National de Génotypage, Evry, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CEA, Institut de Génomique, Centre National de Génotypage, Evry</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mullhaupt, Beat" sort="Mullhaupt, Beat" uniqKey="Mullhaupt B" first="Beat" last="Müllhaupt">Beat Müllhaupt</name>
<affiliation wicri:level="1">
<nlm:aff id="A13">Division of Gastroenterology and Hepatology, University Hospital, Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, University Hospital, Zurich</wicri:regionArea>
<wicri:noRegion>Zurich</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Semela, David" sort="Semela, David" uniqKey="Semela D" first="David" last="Semela">David Semela</name>
<affiliation wicri:level="1">
<nlm:aff id="A14">Division of Gastroenterology, Canton Hospital, St Gallen, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Gastroenterology, Canton Hospital, St Gallen</wicri:regionArea>
<wicri:noRegion>St Gallen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Dufour, Jean Francois" sort="Dufour, Jean Francois" uniqKey="Dufour J" first="Jean-François" last="Dufour">Jean-François Dufour</name>
<affiliation wicri:level="3">
<nlm:aff id="A15">Hepatology, Department of Clinical Research, University Clinic for visceral Surgery and Medicine, Bern, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Hepatology, Department of Clinical Research, University Clinic for visceral Surgery and Medicine, Bern</wicri:regionArea>
<placeName>
<settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Heim, Markus H" sort="Heim, Markus H" uniqKey="Heim M" first="Markus H." last="Heim">Markus H. Heim</name>
<affiliation wicri:level="1">
<nlm:aff id="A16">Division of Gastroenterology and Hepatology, University Hospital, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, University Hospital, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Moradpour, Darius" sort="Moradpour, Darius" uniqKey="Moradpour D" first="Darius" last="Moradpour">Darius Moradpour</name>
<affiliation wicri:level="1">
<nlm:aff id="A17">Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Centre Hospitalier Universitaire Vaudois, University of Lausanne</wicri:regionArea>
<wicri:noRegion>University of Lausanne</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Cerny, Andreas" sort="Cerny, Andreas" uniqKey="Cerny A" first="Andreas" last="Cerny">Andreas Cerny</name>
<affiliation wicri:level="1">
<nlm:aff id="A18">Clinica Moncucco, Lugano, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Clinica Moncucco, Lugano</wicri:regionArea>
<wicri:noRegion>Lugano</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Malinverni, Raffaele" sort="Malinverni, Raffaele" uniqKey="Malinverni R" first="Raffaele" last="Malinverni">Raffaele Malinverni</name>
<affiliation wicri:level="1">
<nlm:aff id="A19">Pourtalès Hospital, Neuchâtel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Pourtalès Hospital, Neuchâtel</wicri:regionArea>
<wicri:noRegion>Neuchâtel</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hirsch, Hans" sort="Hirsch, Hans" uniqKey="Hirsch H" first="Hans" last="Hirsch">Hans Hirsch</name>
<affiliation wicri:level="1">
<nlm:aff id="A20">Institute for Medical Microbiology, University Hospital, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute for Medical Microbiology, University Hospital, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Martinetti, Gladys" sort="Martinetti, Gladys" uniqKey="Martinetti G" first="Gladys" last="Martinetti">Gladys Martinetti</name>
<affiliation wicri:level="1">
<nlm:aff id="A21">Institute of Medical Microbiology, Bellinzona, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Medical Microbiology, Bellinzona</wicri:regionArea>
<wicri:noRegion>Bellinzona</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Suppiah, Vijayaprakash" sort="Suppiah, Vijayaprakash" uniqKey="Suppiah V" first="Vijayaprakash" last="Suppiah">Vijayaprakash Suppiah</name>
<affiliation wicri:level="3">
<nlm:aff id="A22">Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A23">Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author>
<name sortKey="Stewart, Graeme" sort="Stewart, Graeme" uniqKey="Stewart G" first="Graeme" last="Stewart">Graeme Stewart</name>
<affiliation wicri:level="4">
<nlm:aff id="A23">Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author>
<name sortKey="Booth, David R" sort="Booth, David R" uniqKey="Booth D" first="David R." last="Booth">David R. Booth</name>
<affiliation wicri:level="4">
<nlm:aff id="A23">Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author>
<name sortKey="George, Jacob" sort="George, Jacob" uniqKey="George J" first="Jacob" last="George">Jacob George</name>
<affiliation wicri:level="3">
<nlm:aff id="A22">Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney and University of Sydney Medical Foundation, Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name>
<affiliation wicri:level="3">
<nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A8">St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Brechot, Christian" sort="Brechot, Christian" uniqKey="Brechot C" first="Christian" last="Bréchot">Christian Bréchot</name>
<affiliation wicri:level="1">
<nlm:aff id="A24">INSERM U785, Liver Hepatology Centre, Paul Brousse Hospital, University Paris-XI, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U785, Liver Hepatology Centre, Paul Brousse Hospital, University Paris-XI, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Rice, Charles M" sort="Rice, Charles M" uniqKey="Rice C" first="Charles M." last="Rice">Charles M. Rice</name>
<affiliation wicri:level="2">
<nlm:aff id="A25">Center for the Study of Hepatitis C, Rockefeller University, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for the Study of Hepatitis C, Rockefeller University, New York</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Talal, Andrew H" sort="Talal, Andrew H" uniqKey="Talal A" first="Andrew H." last="Talal">Andrew H. Talal</name>
<affiliation wicri:level="2">
<nlm:aff id="A26">Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M." last="Jacobson">Ira M. Jacobson</name>
<affiliation wicri:level="2">
<nlm:aff id="A26">Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bourliere, Marc" sort="Bourliere, Marc" uniqKey="Bourliere M" first="Marc" last="Bourlière">Marc Bourlière</name>
<affiliation wicri:level="1">
<nlm:aff id="A27">Service d’Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d’Hépato-gastroentérologie, Hôpital Saint-Joseph, Marseilles</wicri:regionArea>
<wicri:noRegion>Marseilles</wicri:noRegion>
<wicri:noRegion>Marseilles</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Theodorou, Ioannis" sort="Theodorou, Ioannis" uniqKey="Theodorou I" first="Ioannis" last="Theodorou">Ioannis Theodorou</name>
<affiliation wicri:level="3">
<nlm:aff id="A5">Laboratory of Immunity and Infection, INSERM UMR-S 945, UPMC Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière AP-HP, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Immunity and Infection, INSERM UMR-S 945, UPMC Université Paris 6, Groupe Hospitalier Pitié-Salpêtrière AP-HP, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Poynard, Thierry" sort="Poynard, Thierry" uniqKey="Poynard T" first="Thierry" last="Poynard">Thierry Poynard</name>
<affiliation wicri:level="4">
<nlm:aff id="A28">Université Pierre et Marie Curie, Service d’Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Pierre et Marie Curie, Service d’Hépato-gastroentérologie, Hôpital Pitié-Salpêtrière (AP-HP), Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Pierre-et-Marie-Curie</orgName>
</affiliation>
</author>
<author>
<name sortKey="Negro, Francesco" sort="Negro, Francesco" uniqKey="Negro F" first="Francesco" last="Negro">Francesco Negro</name>
<affiliation wicri:level="1">
<nlm:aff id="A29">Divisions of Gastroenterology and Hepatology and of Clinical Pathology, University Hospital, Geneva, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Divisions of Gastroenterology and Hepatology and of Clinical Pathology, University Hospital, Geneva</wicri:regionArea>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A7">Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département d’Hépatologie, INSERM U1016, Groupe Hospitalier Cochin-Hôtel Dieu-Broca, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bochud, Pierre Yves" sort="Bochud, Pierre Yves" uniqKey="Bochud P" first="Pierre-Yves" last="Bochud">Pierre-Yves Bochud</name>
<affiliation wicri:level="3">
<nlm:aff id="A6">Service of Infectious Diseases, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Service of Infectious Diseases, Department of Medicine, University Hospital and University of Lausanne, Lausanne</wicri:regionArea>
<placeName>
<settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name>
<affiliation wicri:level="3">
<nlm:aff id="A1">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Medical School, Institut National de la Santé et de la Recherche Médicale (INSERM) U980, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A2">University Paris Descartes, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A8">St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>St; Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Gastroenterology</title>
<idno type="ISSN">0016-5085</idno>
<idno type="eISSN">1528-0012</idno>
<imprint>
<date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec id="S1">
<title>BACKGROUND & AIMS</title>
<p id="P2">Polymorphisms in
<italic>IL28B</italic>
were shown to affect clearance of hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We carried out a 2-stage GWA study of liver fibrosis progression related to HCV infection.</p>
</sec>
<sec id="S2">
<title>METHODS</title>
<p id="P3">We studied well-characterized HCV-infected patients of European descent who had liver biopsies before treatment. We defined various liver fibrosis phenotypes on the basis of Metavir scores, with and without taking the duration of HCV infection into account. Our GWA analyses were conducted on a filtered primary cohort of 1161 patients using 780,650 single nucleotide polymorphisms (SNPs). We genotyped 96 SNPs with
<italic>P</italic>
-values<5×10
<sup>−5</sup>
from an independent replication cohort of 962 patients. We then assessed the most interesting replicated SNPs using DNA samples collected from 219 patients who participated in separate GWA studies of HCV clearance.</p>
</sec>
<sec id="S3">
<title>RESULTS</title>
<p id="P4">In the combined cohort of 2342 HCV-infected patients, the SNPs rs16851720 (in the total sample) and rs4374383 (in patients that received blood transfusions) were associated with fibrosis progression (
<italic>
<sub>Pcombined</sub>
</italic>
=8.9×10
<sup>−9</sup>
and 1.1×10
<sup>−9</sup>
, respectively). The SNP rs16851720 is located within
<italic>RNF7</italic>
, which encodes an antioxidant that protects against apoptosis. The SNP rs4374383, together with another replicated SNP, rs9380516 (
<italic>P
<sub>combined</sub>
</italic>
=5.4×10
<sup>−7</sup>
), were linked to the functionally related genes
<italic>MERTK</italic>
and
<italic>TULP1</italic>
, which encode factors involved in phagocytosis of apoptotic cells by macrophages.</p>
</sec>
<sec id="S4">
<title>CONCLUSIONS</title>
<p id="P5">Our GWA study identified several susceptibility loci for HCV-induced liver fibrosis; these were linked to genes that regulate apoptosis. Apoptotic control might therefore be involved in liver fibrosis.</p>
</sec>
</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Australie</li>
<li>France</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region>
<li>Canton de Berne</li>
<li>Canton de Vaud</li>
<li>Nouvelle-Galles du Sud</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement>
<li>Berne</li>
<li>Lausanne</li>
<li>Marseille</li>
<li>Paris</li>
<li>Sydney</li>
<li>Évry (Essonne)</li>
</settlement>
<orgName>
<li>Université Pierre-et-Marie-Curie</li>
<li>Université de Sydney</li>
<li>Université de la Méditerranée</li>
</orgName>
</list>
<tree>
<country name="France">
<region name="Île-de-France">
<name sortKey="Patin, Etienne" sort="Patin, Etienne" uniqKey="Patin E" first="Etienne" last="Patin">Etienne Patin</name>
</region>
<name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name>
<name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name>
<name sortKey="Argiro, Laurent" sort="Argiro, Laurent" uniqKey="Argiro L" first="Laurent" last="Argiro">Laurent Argiro</name>
<name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name>
<name sortKey="Bourliere, Marc" sort="Bourliere, Marc" uniqKey="Bourliere M" first="Marc" last="Bourlière">Marc Bourlière</name>
<name sortKey="Bousquet, Laurence" sort="Bousquet, Laurence" uniqKey="Bousquet L" first="Laurence" last="Bousquet">Laurence Bousquet</name>
<name sortKey="Bousquet, Laurence" sort="Bousquet, Laurence" uniqKey="Bousquet L" first="Laurence" last="Bousquet">Laurence Bousquet</name>
<name sortKey="Brechot, Christian" sort="Brechot, Christian" uniqKey="Brechot C" first="Christian" last="Bréchot">Christian Bréchot</name>
<name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name>
<name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name>
<name sortKey="Guergnon, Julien" sort="Guergnon, Julien" uniqKey="Guergnon J" first="Julien" last="Guergnon">Julien Guergnon</name>
<name sortKey="Halfon, Philippe" sort="Halfon, Philippe" uniqKey="Halfon P" first="Philippe" last="Halfon">Philippe Halfon</name>
<name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name>
<name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name>
<name sortKey="Munteanu, Mona" sort="Munteanu, Mona" uniqKey="Munteanu M" first="Mona" last="Munteanu">Mona Munteanu</name>
<name sortKey="Nalpas, Bertrand" sort="Nalpas, Bertrand" uniqKey="Nalpas B" first="Bertrand" last="Nalpas">Bertrand Nalpas</name>
<name sortKey="Nalpas, Bertrand" sort="Nalpas, Bertrand" uniqKey="Nalpas B" first="Bertrand" last="Nalpas">Bertrand Nalpas</name>
<name sortKey="Patin, Etienne" sort="Patin, Etienne" uniqKey="Patin E" first="Etienne" last="Patin">Etienne Patin</name>
<name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name>
<name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name>
<name sortKey="Poynard, Thierry" sort="Poynard, Thierry" uniqKey="Poynard T" first="Thierry" last="Poynard">Thierry Poynard</name>
<name sortKey="Theodorou, Ioannis" sort="Theodorou, Ioannis" uniqKey="Theodorou I" first="Ioannis" last="Theodorou">Ioannis Theodorou</name>
</country>
<country name="Suisse">
<region name="Canton de Vaud">
<name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name>
</region>
<name sortKey="Bibert, Stephanie" sort="Bibert, Stephanie" uniqKey="Bibert S" first="Stéphanie" last="Bibert">Stéphanie Bibert</name>
<name sortKey="Bochud, Pierre Yves" sort="Bochud, Pierre Yves" uniqKey="Bochud P" first="Pierre-Yves" last="Bochud">Pierre-Yves Bochud</name>
<name sortKey="Cerny, Andreas" sort="Cerny, Andreas" uniqKey="Cerny A" first="Andreas" last="Cerny">Andreas Cerny</name>
<name sortKey="Dufour, Jean Francois" sort="Dufour, Jean Francois" uniqKey="Dufour J" first="Jean-François" last="Dufour">Jean-François Dufour</name>
<name sortKey="Heim, Markus H" sort="Heim, Markus H" uniqKey="Heim M" first="Markus H." last="Heim">Markus H. Heim</name>
<name sortKey="Hirsch, Hans" sort="Hirsch, Hans" uniqKey="Hirsch H" first="Hans" last="Hirsch">Hans Hirsch</name>
<name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name>
<name sortKey="Malinverni, Raffaele" sort="Malinverni, Raffaele" uniqKey="Malinverni R" first="Raffaele" last="Malinverni">Raffaele Malinverni</name>
<name sortKey="Martinetti, Gladys" sort="Martinetti, Gladys" uniqKey="Martinetti G" first="Gladys" last="Martinetti">Gladys Martinetti</name>
<name sortKey="Moradpour, Darius" sort="Moradpour, Darius" uniqKey="Moradpour D" first="Darius" last="Moradpour">Darius Moradpour</name>
<name sortKey="Mullhaupt, Beat" sort="Mullhaupt, Beat" uniqKey="Mullhaupt B" first="Beat" last="Müllhaupt">Beat Müllhaupt</name>
<name sortKey="Negro, Francesco" sort="Negro, Francesco" uniqKey="Negro F" first="Francesco" last="Negro">Francesco Negro</name>
<name sortKey="Semela, David" sort="Semela, David" uniqKey="Semela D" first="David" last="Semela">David Semela</name>
</country>
<country name="États-Unis">
<region name="État de New York">
<name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name>
</region>
<name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name>
<name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name>
<name sortKey="Jacobson, Ira M" sort="Jacobson, Ira M" uniqKey="Jacobson I" first="Ira M." last="Jacobson">Ira M. Jacobson</name>
<name sortKey="Rice, Charles M" sort="Rice, Charles M" uniqKey="Rice C" first="Charles M." last="Rice">Charles M. Rice</name>
<name sortKey="Talal, Andrew H" sort="Talal, Andrew H" uniqKey="Talal A" first="Andrew H." last="Talal">Andrew H. Talal</name>
</country>
<country name="Australie">
<region name="Nouvelle-Galles du Sud">
<name sortKey="Suppiah, Vijayaprakash" sort="Suppiah, Vijayaprakash" uniqKey="Suppiah V" first="Vijayaprakash" last="Suppiah">Vijayaprakash Suppiah</name>
</region>
<name sortKey="Booth, David R" sort="Booth, David R" uniqKey="Booth D" first="David R." last="Booth">David R. Booth</name>
<name sortKey="George, Jacob" sort="George, Jacob" uniqKey="George J" first="Jacob" last="George">Jacob George</name>
<name sortKey="Stewart, Graeme" sort="Stewart, Graeme" uniqKey="Stewart G" first="Graeme" last="Stewart">Graeme Stewart</name>
<name sortKey="Suppiah, Vijayaprakash" sort="Suppiah, Vijayaprakash" uniqKey="Suppiah V" first="Vijayaprakash" last="Suppiah">Vijayaprakash Suppiah</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005376 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005376 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3756935
   |texte=   Genome-Wide Association Study Identifies Variants Associated with Progression of Liver Fibrosis from HCV Infection
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:22841784" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1
Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024